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The Costa Serena sails a 20-night Eastern Mediterranean from Athens itinerary with Costa Cruises, departing Piraeus, Greece on May 20, 2027. It's a classic Mediterranean cruise. Travelers sailing in May can generally expect mild, changeable weather that can turn cool and wet. Ports of call include Piraeus, Greece, Santorini, Greece, Mykonos, Greece, with 16 more along the way. Use the day-by-day forecast below to plan what to pack for each stop.
Piraeus, Greece is a scheduled port of call on day 1 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Santorini, Greece is a scheduled port of call on day 2 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Mykonos, Greece is a scheduled port of call on day 3 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
La Valletta, Malta is a scheduled port of call on day 4 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Ibiza, Spain is a scheduled port of call on day 5 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Valencia, Spain is a scheduled port of call on day 6 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Palma De Mallorca, Spain is a scheduled port of call on day 7 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Marseille, France is a scheduled port of call on day 8 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Savona, Italy is a scheduled port of call on day 9 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Civitavecchia, Italy is a scheduled port of call on day 10 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Naples, Italy is a scheduled port of call on day 11 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Cagliari, Sardinia is a scheduled port of call on day 12 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Palermo, Sicily is a scheduled port of call on day 13 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
La Valletta, Malta is a scheduled port of call on day 14 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Catania, Sicily is a scheduled port of call on day 15 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Taranto, Italy is a scheduled port of call on day 16 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Argostoli, Greece is a scheduled port of call on day 17 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Mykonos, Greece is a scheduled port of call on day 18 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
Piraeus, Greece is a scheduled port of call on day 19 of the 20-night Eastern Mediterranean from Athens cruise on Costa Serena.
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